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Physicians and Surgeons Building
Room 15-401
Tel 212.305.6369
Email lag3@columbia.edu
RESEARCH THEME: The overarching theme of the research in my laboratory is to understand the molecular mechanisms that govern the differentiation, normal developmental death and disease-associated degeneration of neurons. Specific projects now underway include 1) Studying the role of the transcription factors Atf5 and Gata-2 in trophic factor-regulated neuronal differentiation; 2) Working out the molecular pathways by which the transcription factors c-Jun and E2F as well as their downstream pro-apoptotic targets participate in neuron death during development and in neurodegenerative disorders with the goal of interfering with these pathways in disease; 3) Describing and understanding the roles of transcriptionally regulated molecules (eg., RTP801, ATF4, Bim and PUMA) that contribute to neuron death in neurodegenerative disorders, again with the aim of therapeutic targeting. We also maintain an interest in neural tumors and in particular, the role of the above-mentioned ATF5 in their formation, survival and propagation.

BACKGROUND AND EDUCATION : Dr. Greene is a Professor of Pathology with an appointment in the Center for Neurobiology and Behavior. He is also on the teaching faculties of the Departments of Pharmacology and Columbia University Department of Biology. Previously, he served on the faculties of New York Unversity School of Medicine and Harvard Medical School. Dr. Greene received his undergraduate degree from the University of Chicago and his Ph.D. from the University of California, San Diego; both degrees are in chemistry. He was a post-doctoral fellow with Dr. Marshall Nirenberg at the National Institutes of Health.

EDUCATION AND TRAINING:
1965 B.S., Chemistry, University of Chicago
1970 Ph.D. Chemistry, University of California, San Diego, La Jolla


SELECTED PUBLICATIONS :
  • Ryu, ER, Angelastro, JM, and Greene, LA. Analysis of gene expression changes in a cellular model of Parkinson Disease. Neurobiol. Disease. 18: 54-74 (2005).
  • Liu, D.X., Nath, N., Chellappan, SP and Greene, LA. Regulation of neuron survival and death by p130 and associated chromatin modifiers. Genes & Dev. 19: 719-732 (2005).
  • Angelastro, JM, Mason J, Ignatova, T, Kukekov, V, Stengren, G, Goldman, JE, and Greene, LA. Down regulation of ATF5 is required for differentiation of neural progenitor cells into astrocytes. J. Neurosci. 25: 3889-3899 (2005).
  • Biswas, SC, Liu, DX and Greene, LA. Bim is a direct target of a neuronal E2F-dependent apoptotic pathway. J. Neurosci 25: 8349-8358 (2005).
  • Liu, DX, Biswas, SC, and Greene, LA. B-myb and C-myb play required roles in neuronal apoptosis evoked by NGF deprivation and DNA damage. J. Neurosci. . J. Neurosci. 24: 8720-8725 (2004).
  • Xu, Z., Kukekov, NV and Greene LA. POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J. 22: 252-261 (2003).


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