Motor Neuron Center
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Email jwk18@columbia.edu
RESEARCH THEME: 1. Motor learning in healthy human subjects: (a)Adaptation of human reaching movements to novel kinematic and dynamic transformations. (b) Consolidation of motor memory and how implicit cues allow retrieval of motor memories. (c) Functional brain imaging of motor learning. 2. Stroke recovery and its relation to motor learning. (a) Quantitative movement analysis of reaching movements after stroke and in response to rehabilitation. (b) Functional imaging of brain reorganization after stroke.

BACKGROUND AND EDUCATION : John W. Krakauer is an assistant professor of neurology at Columbia University College of Physicians and Surgeons. He is codirector of the Motor Performance Laboratory at the Neurological Institute.

He obtained his B.A. from Cambridge University and received his M.D. from Columbia University College of Physicians and Surgeons. He did his internship at Johns Hopkins Hospital and his neurology residency at Columbia University Medical Center. He did a research fellowship in motor control in the laboratory of Dr. Claude Ghez at the Center for Neurobiology and Behavior at Columbia University. He completed a stroke fellowship at the Neurological Institute, Columbia University Medical Center.

Dr. Krakauer's research has been NIH funded and his interests include (1) trajectory control and motor learning during reaching movements in healthy subjects and in patients with stroke; and (2) functional brain imaging of motor learning and stroke recovery.

Dr. Krakauer's clinical interest is stroke, including ischemic cerebrovascular disease, subarachnoid and intracerebral hemorrhage, arteriovenous malformation, cerebral vasculitis, cerebral aneurysm, and venous and sinus thrombosis.

EDUCATION AND TRAINING:
1984-87 BA, Trinity College, Cambridge University
1988-92 M.D., Columbia University College of Physicians and Surgeons
1992-93 Internship (Internal medicine), Johns Hopkins Hospital
1993-96 Residency (Neurology), Columbia University Medical Center
1996-97 Research Fellowship (Motor Control), Center for Neurobiology and Behavior,Columbia University
1997-98 Clinical Fellowship (Stroke), Columbia University Medical Center


SELECTED PUBLICATIONS :
  • Krakauer JW and Shadmehr R. Consolidation of motor memory Trends in Neurosci (in press).
  • Krakauer JW, Ghez C, Ghilardi MF.Adaptation to visuomotor transformations: consolidation, interference, and forgetting. J Neurosci. 2005 Jan 12;25(2):473-8.
  • Krakauer JW, Radoeva PD, Zarahn E, Wydra J, Lazar RM, Hirsch J, Marshall RS. Hypoperfusion without stroke alters motor activation in the opposite hemisphere. Ann Neurol. 2004 Dec;56(6):796-802.
  • Krakauer JW, Ghilardi MF, Mentis M, Barnes A, Veytsman M, Eidelberg D, Ghez C.Differential cortical and subcortical activations in learning rotations and gains for reaching: a PET study. J Neurophysiol. 2004 Feb;91(2):924-33.
  • Krakauer JW, Pine ZM, Ghilardi MF, Ghez C.Learning of visuomotor transformations for vectorial planning of reaching trajectories. J Neurosci. 2000 Dec 1;20(23):8916-24
  • Krakauer JW, Ghilardi MF, Ghez C. Independent learning of internal models for kinematic and dynamic control of reaching. Nat Neurosci. 1999 Nov;2(11):1026-31.