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Immunohistochemical analysis of spinal cord sections from transgenic mice expressing mutant SOD1 for motor neurons (neurofilament) and microglia (Mac-1). Note: the fewer motor neurons in symptomatic transgenic mutant SOD1 mice with normal inflammatory function (E) compared to age-matched transgenic mutant mice with defective inflammatory function (F). D shows a spinal cord section of an age-matched non transgenic control. In both transgenic mice expressing mutant SOD1 with or without a normal inflammatory function there is a robust microglial activation (N, O) compared to the non transgenic control (M). |
