News Related to: New Insights on How the Reprogramming Factor LIN28 Regulates its Targets
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ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function
Mutations in FUS cause amyotrophic lateral sclerosis (ALS), including some of the most aggressive, juvenile-onset forms of the disease. FUS loss-of-function and toxic gain-of...
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Role of Primary Afferents in the Developmental Regulation of Motor Axon Synapse Numbers on Renshaw Cells
Motor function in mammalian species depends on the
maturation of spinal circuits formed by a large variety
of interneurons that regulate motoneuron firing and
motor output... -
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function
The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS and FTD remain controversial. We propose a model in which low-complexity (LC) domains of FUS drive its...
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ALS Association and Target ALS to Expand Tissue Core for ALS Research
The ALS Association and Target ALS are pleased to announce the launch of a new collaborative effort to expand the collection of biofluids from people with ALS, to be used for research to better...
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New ALS Gene and Signaling Pathways Identified
Findings point to potential therapeutic targets
NEW YORK, NY (February 19, 2015)
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The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis
The discovery of key mediators of neurodegenerative phenotypes, especially...
